Drug

Typical Dosing

Amoxicillin

Amoxil^®, Trimox^®

Generics available

Pregnancy: B; Lactation: Safe

Caps:

250 mg, 500 mg

Tabs: 500 mg, 875 mg

Chewable Tab: 125 mg,  250 mg,

Oral Susp:

125 mg/5 mL

250 mg/5 mL

200 mg/5 mL

400 mg/5 mL

Neonates and infants ≤3 months: 20-30 mg/kg/day in divided doses Q12H.

Children >3 months: 25-50 mg/kg/day (max 2-3 g/day) in divided doses Q8H or Q12H.

250 mg/5 mL at 50 mg/kg/day

10 kg (22 lb) = 1 tsp (5 mL) Q12H

15 kg (33 lb) = 1 tsp (5 mL) Q8H

20 kg (44 lb) = 2 tsp (10 mL) Q12H

>25 kg = Use adult dose.

Adult: 250-500 mg PO Q8H or 500-875 mg PO Q12H.

Food: May take with or without meals.

Important side effects: Nausea, vomiting, diarrhea, agitation, seizures, rash, bleeding abnormalities, decreased WBC count, drug fever, superinfection.

Caution: May cause nonallergic maculopapular rash, especially in patients with viral infection, infectious mononucleosis, or acute lymphocytic leukemia.

Reduce dose in renal disease:

CrCl 10-30 mL/min administer every 12 hours

CrCl <10 mL/min administer every 24 hours