GENITOURINARY - Bacterial Vaginosis (Anaerobes, Gardnerella vaginalis, Mycoplasma hominis, polymicrobial)

 

 

Metronidazole*

(Flagyl®)

Generics available

Pregnancy: B; Lactation: Unsafe

Tabs: 250 mg, 500 mg  

 

Adult: 500 mg twice daily for 7 days or 2 g given as a one time dose. (2-g dosing may be less effective than the 7-day regimen.)

 

Food: Administer on empty stomach unless GI upset occurs, then with food.

 

Important side effects: Dizziness, headache, confusion, seizures, nausea, metallic taste, insomnia, paresthesias.

May cause Disulfiram-like reaction - avoid alcohol.

 

 

 

Clindamycin Vaginal Cream*

(Cleocin®)

Pregnancy: B; Lactation: Unknown

 

Vaginal Cream 2%: 40 g

 

 

Adolescent and Adult: Insert one applicator (5 g) intravaginally each night at bedtime for 7 days.

 

Important side effects: May weaken latex condoms or diaphragms. Advise patient not to engage in vaginal intercourse while using this product.

 

 

Metronidazole gel*

(MetroGel®-Vaginal)

Pregnancy: B; Lactation: Unk

 

Gel, vaginal 0.75%: 70 g

 

 

Adult: Insert one applicator (5 g) intravaginally twice daily for 5 days.

 

 

Clindamycin*

(Cleocin®)

Generics available

Pregnancy: B; Lactation: Unk

 

Caps: 150 mg -  , 300 mg     

 

Adult: 300 mg twice daily for 7 days.

 

*May cause severe colitis. Encourage patient to report severe, persistent, or bloody diarrhea.

 

 

Food: May administer without regard to food. Take with full glass of water to prevent esophagitis.

 

Important side effects: Diarrhea (may be severe), esophagitis.