Drug	Typical Dosing

Cefaclor Ceclor^® Pregnancy: B; Lactation: Use with caution Caps: 250 mg, 500 mg Tabs, Extended Release (ER): 500 mg Powder for Oral Suspension: 125 mg/5 mL 250 mg/5 mL 375 mg/5 mL

Important side effects: Nausea, diarrhea, elevated LFTs. Caution: Significant drug interactions may occur with pimozide (avoid), cyclosporine, HMG-CoA reductase inhibitors. Use with caution in hepatic disease. Children ≥1 month: Usual dose: 20 mg/kg/day (max 1,000 mg/day) in divided doses every 8 hours. Severe or Otitis Media: 40 mg/kg/day (max 1,000 mg/day) in divided doses every 8 or 12 hours. 125 mg/5 mL @ 20 mg/kg/day (double for 40 mg/kg/day) 9 kg (20 lb) = ^1/2 tsp (2.5 mL) Q8H 18 kg (40 lb) = 1 tsp (5 mL) Q8H 250 mg/5 mL @ 20 mg/kg/day (double for 40 mg/kg/day) 18 kg (40 lb) = ^1/2 tsp (2.5 mL) Q8H 27 kg (50 lb) = ^3/4 tsp Q8H 36 kg (80 lb) = 1 tsp (5 mL) Q8H Child ≥36 kg and Adult: Capsules: 250-500 mg PO every 8 hours Extended release tablets: 375-500 mg PO every 12 hours Food: Capsules and oral suspension may be taken without regard to food. May take with food to reduce GI upset. Tablets should be taken with food. Important side effects: Nausea, vomiting, diarrhea, rash, elevated LFTs. Caution: Avoid use in patients with history of severe penicillin allergy. Use with caution in patients with history of seizures. Reduce dose in severe renal disease: CrCl <10 mL/min administer 50% of the usual dose.