Drug

 

 

Typical Dosing

 

 

Cefpodoxime

Vantin®

Pregnancy: B; Lactation: Unsafe

 

Tabs:

100 mg

200 mg

 

Granules for Oral Suspension:

50 mg/5 mL

100 mg/5 mL

 

Children ≥5 months to 12 years:

10 mg/kg/day in one or two divided doses (max 400 mg/day).

 

50 mg/5 mL @ 10 mg/kg/day

10 kg (22 lb) = 1 tsp (5 mL) Q12H or 2 tsp (10 mL) daily

15 kg (33 lb) = 11/2 tsp (7.5 mL) Q12H or 3 tsp (15 mL) daily

 

100 mg/5 mL @10 mg/kg/day

15 kg (33 lb) = 3/4 tsp Q12H or 11/2 tsp (7.5 mL) daily

20 kg (44 lb) = 1 tsp (5 mL) Q12H

30 kg (66 lb) = 11/2 tsp (7.5 mL) Q12H or 3 tsp (15 mL) daily

40 kg (88 lb) = Use adult dose.

 

≥12 years to Adult: 100-400 mg two times daily.

 

Food: Take tablet with food. Suspension may be taken without regard to food.

 

Important side effects: Nausea, vomiting, rash, diarrhea, elevated LFTs.

 

Caution: Avoid use in patients with history of severe penicillin allergy. Use with caution in patients with history of seizures.

 

Reduce dose in renal disease.

CrCl <30 mL/min decrease dosing interval to once daily.