Drug

Typical Dosing

Cefuroxime axetil (Ceftin^®) Pregnancy: B; Lactation: Unsafe Tabs: 125 mg 250 mg 500 mg Powder for Oral Suspension: 125 mg/5 mL 250 mg/5 mL Note: Tablets and oral suspension are not considered bioequivalent and cannot be directly substituted on a mg/mg basis.

Children ≥3 months to 12 years: 20-30 mg/kg/day in divided doses 2 times daily (maximum 1,000 mg/day). 125 mg/5 mL @ 20 mg/kg/day 6 kg (13 lb) = ^1/2 tsp (2.5 mL) Q12H 12 kg (26 lb) = 1 tsp (5 mL) Q12H 18 kg (40 lb) = 1^1/2 tsp (7.5 mL) Q12H 125 mg/5 mL @ 30 mg/kg/day 8 kg (18 lb) = 1 tsp (5 mL) Q12H 12.5 kg (27 lb) = 1^1/2 tsp (7.5 mL) Q12H 17 kg (37 lb) = 2 tsp (10 mL) Q12H 25 kg (55 lb) = 1 tbsp (15 mL) Q12H 33 kg (73 lb) = Use adult dose. 250 mg/5 mL @ 30 mg/kg/day 8 kg (18 lb) = ^1/2 tsp (2.5 mL) Q12H 16 kg (36 lb) = 1 tsp (5 mL) Q12H 24 kg (54 lb) = 1^1/2 tsp (7.5 mL) Q12H ≥13 years to Adult: 250-500 mg Q12H. Food: Suspension should be taken with food. Tablets may be taken without regard to food. May administer with food to reduce GI upset. Important side effects: Nausea, vomiting, rash, diarrhea, elevated LFTs. Caution: Avoid use in patients with history of severe penicillin allergy. Use with caution in patients with history of seizures. Reduce dose in renal disease: CrCl 10-29 mL/min give standard dose every 24 hours CrCl <10 mL/min give standard dose every 48 hours