SKIN - Cellulitis - Mild (Staphylococcus aureus, Group A Streptococcus)
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Cephalexin (Keflex®) Generics available Pregnancy: B; Lactation: Unk
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Children: 25-100 mg/kg/day (max 4 g/day) in divided doses three or four times daily for 10-14 days.
125 mg/5 mL @ 25 mg/kg/day (double for 50 mg/kg) 10 kg (22 lb) = ½ tsp (2.5 mL) Q6H 15 kg (33 lb) = ¾ tsp Q6H 20 kg (44 lb) = 1 tsp (5 mL) Q6H
250 mg/5 mL @ 25 mg/kg/day (double for 50 mg/kg) 20 kg (44 lb) = ½ tsp (2.5 mL) Q6H 40 kg (88 lb) = 1 tsp (5 mL) Q6H >40 kg = Use adult dose.
Adult: 500 mg PO four times daily for 10-14 days.
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Food: May take with food if GI upset occurs.
Important side effects: GI upset, diarrhea. |
Tabs: 250 mg, 500 mg, 1 g Caps: 250 mg, 500 mg Oral Susp: 125 mg/5 mL, 250 mg/5 mL
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Reduce dose in renal disease (CrCl <40 mL/min). |
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Dicloxacillin (Dynapen®) Generics available Pregnancy: B; Lactation: Unk
Caps: 125 mg, 250 mg, 500 mg Oral Susp: 62.5 mg/5 mL, 200 mL |
Children ≤40 kg: 25-50 mg/kg/day (max 2 g/day) in divided doses every 6 hours for 10-14 days.
62.5 mg/5 mL @ 25 mg/kg/day (double for 50 mg) 10 kg (22 lb) = 1 tsp (5 mL) Q6H 15 kg (33 lb) = 1½ tsp (7.5 mL) Q6H 20 kg (44 lb) = 2 tsp (10 mL) Q6H 40 kg (88 lb) = Use adult dose.
Children ≥40 kg and Adult: 250-500 mg PO four times daily for 10-14 days.
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Food: Take 1 hour before or 2 hours after meals.
Important side effects: Bad taste, GI upset; may reduce efficacy of oral contraceptives. |
Erythromycin estolate or base An alternative for patients with beta-lactam intolerance. |
Children: 30-50 mg/kg/day estolate (max 2 g/day) in two to four divided doses a day for 10-14 days.
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Food: May take with or without meals. Take with food if causes GI upset. |
(E-mycin®, Ilosone ®) Generics available Pregnancy: B; Lactation: Unsafe
Estolate: Tabs: 500 mg Caps: 250 mg Oral Susp: 125 mg/5 mL, 250 mg/5 mL
Base: Tabs: 250 mg, 333 mg, 500 mg Caps: 250 mg
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125 mg/5 mL @ 30 mg/kg/day 4 kg (10 lb) = ½ tsp (2.5 mL) Q12H 5-8 kg (11-18 lb) = 1 tsp (5 mL) Q12H 9-12 kg (20-26 lb) = 1 tsp (5 mL) Q8H 13-16 kg (29-35 lb) = 1 tsp (5 mL) Q6H or 2 tsp (10 mL) Q12H
250 mg/5 mL @ 30 mg/kg/day 13-16 kg (29-35 lb) = 1 tsp (5 mL) Q12H 17-25 kg (37-55 lb) = 1½ tsp (7.5 mL) Q12H or 1 tsp (5 mL) Q8H 26-33 kg (57-72 lb) = 250 mg Q6H or 500 mg Q12H |
Important side effects: GI upset, hepatitis. |
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30-50 kg (66-110 lb) = 500 mg Q8H
Adult: Erythromycin base or estolate 500 mg PO four times daily for 10-14 days.
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Levofloxacin (Levaquin®) Pregnancy: C; Lactation: Unsafe Tabs: 250 mg, 500 mg |
Adult: 500 mg PO once daily for 7-14 days. |
Food: May take with or without meals. Do not take within 2 hours of antacids, magnesium, calcium supplements, zinc, aluminum, sucralfate, vitamins, or minerals (iron or zinc).
Important side effects:Photosensitivity, dizziness.
Reduce dose in renal disease (CrCl <50 mL/min).
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