Drug

Typical Dosing

Cephalexin Keflex^® Generics available Pregnancy: B; Lactation: Unk Caps: 250 mg 500 mg Tabs: 250 mg 500 mg 1 g Powder for Oral Suspension: 125 mg/5 mL 250 mg/5 mL

Children: Usual dose 25-50 mg/kg/day in divided doses 2 to 4 times daily (max 4 g/day). 125 mg/5 mL @ 25 mg/kg/day (double for 50 mg/kg/day) 10 kg (22 lb) = 1 tsp (5 mL) Q12H 15 kg (33 lb) = 1 tsp (5 mL) Q8H 250 mg/5 mL @ 25 mg/kg/day (double for 50 mg/kg/day) 20 kg (44 lb) = 1 tsp (5 mL) Q12H or ^1/2 tsp (2.5 mL) Q6H 40 kg (88 lb) = 1 tsp (5 mL) Q6H >40 kg = Use adult dose. Adult: 1-4 g daily in 2 to 4 divided doses. Food: May take with food if GI upset occurs. Important side effects: Nausea, vomiting, rash, diarrhea, elevated LFTs. Caution: Avoid use in patients with history of severe penicillin allergy. Use with caution in patients with history of seizures. Reduce dose in renal disease: CrCl 10-40 mL/min give standard dose every 8-12 hours CrCl <10 mL/min give standard dose every 12-24 hours