Bronchopulmonary - Acute Bacterial Exacerbation of Chronic Bronchitis, Without Comorbid Illnesses (Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumoniae) (Value of antibiotic therapy in immunocompetent patients is debatable and generally discouraged.)
Amoxicillin (Amoxil^®) Generics available Pregnancy: B; Lactation: Safe Caps: 250, 500 mg Tabs: 500 mg, 875 mg	Adult: 500 mg PO three times daily or 875 mg two times daily for 10 days.	Food: May take with or without meals. Important side effects: Diarrhea and nausea. May cause nonallergic maculopapular rash. Reduce dose in severe renal disease (CrCl <30 mL/min).
Ampicillin Principen^®, Omnipen^® Generics available Pregnancy: B; Lactation: Unknown Caps: 250 mg, 500 mg	Adults: 500 mg PO four times daily ´ 10 days.	Food: Administer on an empty stomach 1-2 hours before food. Important side effects: Nausea, vomiting, diarrhea, agitation, seizures, rash, bleeding abnormalities, decreased WBC count, drug fever, superinfection. Reduce dose in severe renal disease (CrCl <30 mL/min).
Azithromycin (Zithromax^®) Pregnancy: B; Lactation: Unk	Adult: Dispense one Z-Pak.	Food: Tablets may be taken without regard to food. Important side effects: Nausea, diarrhea, elevated LFTs.
Tabs: 250 mg and Z-Pak
Cefpodoxime (Vantin^®) Pregnancy: B; Lactation: Unk Tabs: 100 mg, 200 mg	Adult: 200 mg PO two times daily for 10 days.	Food: Take tablet with food. Suspension may be taken without regard to food. Important side effects: Nausea, vomiting, rash, diarrhea, elevated LFTs.
Clarithromycin (Biaxin, Biaxin XL^®) Pregnancy: C; Lactation: Unk Tabs: 250 mg, 500 mg	Adult: 500 mg twice daily or 1 g XL once daily for 10 days.	Food: Extended release tablet with food. Others without regard to food. Important side effects: Nausea, drug interactions.
Extended Release Tab (XL): 500 mg		Reduce dose in severe renal disease (CrCl <30 mL/min).
Doxycycline (Vibramycin^®) Generics available Pregnancy: D; Lactation: Unsafe Caps: 50 mg, 100 mg Tabs: 50 mg, 100 mg	Adult: 100 mg PO twice daily for 10 days. May not be active against H. influenzae.	Food: May take with food if GI upset occurs. Take 1 hour before or 2 hours after antacids, iron, milk, or other dairy products. Take with full glass of water to prevent esophagitis. Important side effects: Photosensitivity, (use sunscreen), esophagitis. May discolor fingernails.
Trimethoprim/Sulfamethoxazole (Bactrim^®, Septra^®) Generics available Pregnancy: C; Lactation: Unsafe Single Strength (SS)Tabs: 80 mg/400 mg Double Strength (DS) Tabs: 160 mg/800 mg	Adult: 1 DS tablet PO twice daily for 10 days.	Food: May take without regard to food. Important side effects: photosensitivity, rash. Reduce dose in severe renal disease (CrCl <30 mL/min).
BRONCHOPULMONARY - Acute Bacterial Exacerbation of Chronic Bronchitis, With Comorbid Illnesses (i.e., CHF, diabetes, CRF, chronic liver disease, >65 years, four exacerbations a year) (Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumoniae) Comment: Typically affects smokers or ex-smokers. This group often has risk factors for treatment failure and resistant bacteria. Often responds to oral prednisone. (Value of antibiotic therapy in immunocompetent patients is debatable.)
Amoxicillin/clavulanate (Augmentin^®) Pregnancy: B; Lactation: Unk Q12H Formulations: Tabs: 500 mg/125 mg, 875 mg/125 mg	Adult: 500-875 mg twice daily for 10 days.	Food: Take with food to reduce diarrhea. Important side effects: Diarrhea (common), nausea, rash. Reduce dose in severe renal disease (CrCl <30 mL/min).
Ciprofloxacin If suspect Pseudomonas (Cipro^®) Pregnancy: C; Lactation: Unsafe Tabs: 250 mg, 500 mg, 750 mg	>18 years to Adult: 500-750 mg twice daily for 10 days.	Food: May take with food if it causes GI upset, but avoid large amounts of dairy products. May take 2 hours before or 6 hours after sucralfate, antacids, aluminum, magnesium, calcium, zinc, iron, vitamins, or mineral supplements.
		Important side effects: Photosensitivity, dizziness, headache, insomnia.
		Reduce dose in severe renal disease (CrCl <50 mL/min).
Levofloxacin (Levaquin^®) Pregnancy: C; Lactation: Unsafe Tabs: 250 mg, 500 mg	Adult: 500 mg PO once daily for 7-10 days.	Food: May take without regard to food. Do not take within 2 hours of sucralfate, antacids, aluminum, magnesium, calcium, zinc, iron, vitamins, or mineral supplements. Important side effects: hotosensitivity, dizziness. Reduce dose in severe renal disease (CrCl <50 mL/min).
Moxifloxacin (Avelox^®) Pregnancy: C; Lactation: Unsafe Tabs: 400 mg	>18 years to Adult: 400 mg PO once daily 5 days.	Food: May take without regard to food. Must take 4 hours before or 8 hours after sucralfate, antacids, aluminum, magnesium, calcium, zinc, iron, vitamins, or mineral supplements. Important side effects: hotosensitivity, dizziness, headache, insomnia.