Drug

 

 

Typical Dosing

 

Clotrimazole

(Mycelex®, Lotrimin®,

Gyne-Lotrimin®, Fungoid®)

Pregnancy: C (troche) B (others);

Lactation: Unk

 

Troche: 10 mg

 

Vaginal tablet (OTC):

100 mg (7’s)

200 mg (3’s)

500 mg (1’s)

 

Vaginal cream 1% (OTC):

45 g with applicator

 

Topical cream 1%

 

Topical solution 1%

 

Topical lotion 1%

 

Oral Troche

Children ≥3 years and Adults: Dissolve one troche in mouth slowly (15-30 minutes) 5 times daily for 7-10 days or until 2-3 days after symptoms cleared.

 

Important side effects: Nausea, unpleasant sensation in mouth, elevated LFTs.

 

Use with caution in liver disease.

 

Vaginal Products

Adolescents and Adult - vaginal tablet:

100 mg tablet intravaginally at bedtime × 7 days or

200 mg tablet intravaginally at bedtime × 3 days or

500 mg tablet intravaginally at bedtime once.

 

Adolescent and Adult - vaginal cream:

One applicator intravaginally at bedtime × 7 days. Remain lying down for 30 minutes after application. Avoid intercourse during therapy. Do not use tampons until therapy is complete. Cream or vaginal tablets may weaken latex condoms and diaphragms.

Important side effects: Rash, burning, irritation, cramping.

 

Topical Products

Gently massage into affected area two times daily after washing and drying. Relief of pruritus usually occurs within 1 week. If no clinical improvement after 4 weeks, reevaluate.

Important side effects: Local irritation.

Caution: Avoid contact with eye(s).