SKIN - Diabetic Foot Mild-Moderate (Staphylococcus aureus, beta-hemolytic streptococci, gram negatives, anaerobes) Non-limb-threatening infections may be treated with oral antibiotics in an outpatient setting. More severe infections, or those in an ischemic limb, require surgical consultation and often intravenous therapy.
Cephalexin (Keflex^®) Generics available Pregnancy: B; Lactation: Unk Tabs: 250 mg, 500 mg, 1 g Caps: 250 mg, 500 mg	Adult: 500 mg PO four times daily for 14 days.	Food: May take with food if GI upset occurs. Important side effects: GI upset, diarrhea. Reduce dose in renal disease (CrCl <40 mL/min).
Clindamycin (Cleocin^®) Generics available Pregnancy: B; Lactation: Unk Caps: 75 mg, 150 mg, 300 mg -	Adult: 300 mg PO four times daily for 14 days.	Food: May take with or without meals. Take with full glass of water to prevent esophagitis. Important side effects: Diarrhea (may be severe), nausea. *May cause severe colitis. Encourage patient to report severe, persistent, or bloody diarrhea.
Amoxicillin/clavulanate (Augmentin^®) Pregnancy: B; Lactation: Unk	Adult: 500-875 mg twice daily for 14 days. Note: Q12H dosing may improve compliance compared to Q8H dosing.	Food: Take with food to reduce diarrhea. Important side effects: Diarrhea (common), nausea, rash.
Q12H Formulations: Tabs: 500 mg/125 mg, 875 mg/125 mg		Use cautiously in hepatic disease. Reduce dose in renal disease (CrCl <30 mL/min).
Levofloxacin Alternative for failure of above drug. (Levaquin^®) Pregnancy: C; Lactation: Unsafe Tabs: 250 mg, 500 mg	Adult: 500 mg PO once daily for 14 days.	Food: May take with or without meals. Do not take within 2 hours of antacids, magnesium, calcium supplements, zinc, aluminum, sucralfate, vitamins, or minerals (iron or zinc). Important side effects: Photosensitivity, dizziness. Reduce dose in renal disease (CrCl <50 mL/min).
Trimethoprim/Sulfamethoxazole (Bactrim^®, Septra^®) Generics available Pregnancy: C; Lactation: Unsafe Single Strength (SS) Tabs 80/400 Double Strength (DS) Tabs 160/800	Adult: 1 DS Tab Q12H for 10-14 days.	Food: May take without regard to food. Encourage fluids. Important side effects: Photosensitivity, rash. Reduce dose in renal disease
		(CrCl <30 mL/min).