SKIN - Erysipelas, Mild to Moderate, Nondiabetic Person (Group A Streptococcus, occasionally other Streptococcus sp., Staphylococcus aureus) Severe infections likely need inpatient antibiotics.
Penicillin V Potassium A drug of choice, especially if staph is unlikely. (Pen Vee K^®) Generics available Pregnancy: B; Lactation: Unsafe Tabs: 125 mg, 250 mg, 500 mg	Children <12 years: 25-50 mg/kg/day (max 2 g/day) PO in divided doses Q6H for 10 days. 125 mg/5 mL @ 25 mg/kg/day 10 kg (22 lb) = ½ tsp (2.5 mL) Q6H 15 kg (33 lb) = ¾ tsp Q6H	Food: Take 1 hour before or 2 hours after meals. May take with food if GI upset occurs. Important side effects: Nausea, rash. Use with caution if history of seizure disorder.
Oral Susp: 125 mg/5 mL, 250 mg/5 mL	20 kg (44 lb) = 1 tsp (5 mL) Q6H >20 kg (44 lb) = Use adult dose. 250 mg/5 mL @ 50 mg/kg/day 10 kg (22 lb) = ½ tsp (2.5 mL) Q6H 15 kg (33 lb) = ¾ tsp Q6H 20 kg (44 lb) = 1 tsp (5 mL) Q6H >20 kg (44 lb) = Use adult dose.
Cephalexin (Keflex^®) Generics available Pregnancy: B; Lactation: Unk Tabs: 250 mg, 500 mg, 1 g Caps: 250 mg, 500 mg Oral Susp: 125 mg/5 mL, 250 mg/5 mL	Children ≥12 years and Adult: 500 mg PO Q6H for 10-14 days. Children: 25-100 mg/kg/day (max 4 g/day) PO in divided doses three or four times daily for 10-14 days. 125 mg/5 mL @ 25 mg/kg/day (double for 50 mg/kg) 10 kg (22 lb) = ½ tsp (2.5 mL) Q6H 15 kg (33 lb) = ¾ tsp Q6H 20 kg (44 lb) = 1 tsp (5 mL) Q6H 250 mg/5 mL @ 25 mg/kg/day (double for 50 mg/kg) 20 kg (44 lb) = ½ tsp (2.5 mL) Q6H 40 kg (88 lb) = 1 tsp (5 mL) Q6H >40 kg = Use adult dose. Adult: 500 mg PO four times daily for 10-14 days.	Food: May take with food if GI upset occurs. Important side effects: GI upset, diarrhea. Reduce dose in renal disease (CrCl <40 mL/min).
Dicloxacillin A drug of choice, especially if staph is suspected. (Dynapen^®) Generics available Pregnancy: B; Lactation: Unk Caps: 125 mg, 250 mg, 500 mg Oral Susp: 62.5 mg/5 mL, 200 mL	Children ≤40 kg: 25-50 mg/kg/day (max 2 g/day) in divided doses every 6 hours for 10-14 days. 62.5 mg/5 mL @ 25 mg/kg/day (double for 50 mg) 10 kg (22 lb) = 1 tsp (5 mL) Q6H 15 kg (33 lb) = 1½ tsp (7.5 mL) Q6H 20 kg (44 lb) = 2 tsp (10 mL) Q6H 40 kg (88 lb) = Use adult dose. Children ≥40 kg and Adult: 250-500 mg PO four times daily for 10-14 days.	Food: Take 1 hour before or 2 hours after meals. Important side effects: Bad taste, GI upset.
Erythromycin estolate or base An alternative for patients with beta-lactam intolerance. (E-mycin^®, Ilosone^®) Generics available Pregnancy: B; Lactation: Unsafe Estolate: Tabs: 500 mg Caps: 250 mg Oral Susp: 125 mg/5 mL, 250 mg/5 mL Base: Tabs: 250 mg, 333 mg, 500 mg Caps: 250 mg	Children: 30-50 mg/kg/day estolate (max 2 g/day) in two to four divided doses daily for 10-14 days. 125 mg/5 mL @ 30 mg/kg/day 4 kg (10 lb) = ½ tsp (2.5 mL) Q12H 5-8 kg (11-18 lb) = 1 tsp (5 mL) Q12H 9-12 kg (20-26 lb) = 1 tsp (5 mL) Q8H 13-16 kg (29-35 lb) = 1 tsp (5 mL) Q6H or 2 tsp (10 mL) Q12H 250 mg/5 mL @ 30 mg/kg/day 13-16 kg (29-35 lb) = 1 tsp (5 mL) Q12H 17-25 kg (37-55 lb) = 1½ tsp (7.5 mL) Q12H or 1 tsp (5 mL) Q8H 26-33 kg (57-72 lb) = 250 mg Q6H or 500 mg Q12H 30-50 kg (66-110 lb) = 500 mg Q8H Adult: Erythromycin base or estolate 500 mg PO four times daily for 10-14 days.	Food: May take with or without meals. Take with food if causes GI upset. Important side effects: GI upset, hepatitis.