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Drug
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Typical Dosing |
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Erythromycin base E-Mycin®, Ery-Tab® Generics available Pregnancy: B; Lactation: Safe
Tabs: 250 mg 333 mg 500 mg Caps: 250 mg
Erythromycin base tablets and capsules are coated or delayed release to minimize GI irritation. They should not be chewed or crushed. |
Children: 30-50 mg/kg/day in divided doses every 6 to 8 hours (max 2,000 mg/day).
Adult: 250-500 mg every 6 to 12 hours or 333 mg PO every 8 hours.
Food: Take 1 hour before or 2 hours after meals. If GI upset occurs may take with food.
Important side effects: Diarrhea, nausea, vomiting, headache, abdominal pain, dizziness, elevated LFTs, superinfection, rash, hearing loss, cardiac arrhythmias. Advise patient to contact provider if prodromal signs of liver dysfunction occur, i.e., abdominal pain, yellowing of skin or eye(s), unusual tiredness, dark urine, or pale stools.
Caution: Drug interactions may be significant, especially pimozide (avoid), alfentanil, bromocriptine, felodipine, sparfloxacin (avoid), grepafloxacin, methylprednisolone, rifampin, warfarin, benzodiazepines, buspirone, carbamazepine, digoxin, cyclosporine, ergots, disopyramide, tacrolimus, HMG-CoA reductase inhibitors, theophylline, zidovudine, cisapride, others.
Use with caution in persons with liver disease.
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Erythromycin Estolate Ilosone® Generics available Pregnancy: B; Lactation: Safe
Tabs: 500 mg Caps: 250 mg
Oral Suspension: 125 mg/5 mL 250 mg/5 mL |
Children: 30-50 mg/kg/day in divided doses every 6 to 12 hours (max 2,000 mg/day).
30 mg/kg/day with 125 mg/5 mL 4 kg (9 lb) = 1/2 tsp (2.5 mL) Q12H 6 kg (14 lb) = 1/2 tsp (2.5 mL) Q8H 8 kg (18 lb) = 1/2 tsp (2.5 mL) Q6H or 1 tsp (5 mL) Q12H 12 kg (27 lb) = 1 tsp (5 mL) Q8H 17 kg (36 lb) = 1 tsp (5 mL) Q6H or 2 tsp (10 mL) Q12H
30 mg/kg/day with 250 mg/5 mL 12 kg (27 lb) = 1/2 tsp (2.5 mL) Q8H 17 kg (36 lb) = 1/2 tsp (2.5 mL) Q6H or 1 tsp (5 mL) Q12H 25 kg (55 lb) = 1 tsp (5 mL) Q8H 33 kg (73 lb) = 1 tsp (5 mL) Q6H or 2 tsp (10 mL) Q12H
Adult: 250-500 mg PO every 6 to 12 hours.
Food: Take 1 hour before or 2 hours after meals. If GI upset occurs may take with food.
Important side effects: Diarrhea, nausea, vomiting, headache, abdominal pain, dizziness, elevated LFTs, superinfection, rash, hearing loss, cardiac arrhythmias.
Advise patient to contact provider if prodromal signs of liver dysfunction occur, i.e., abdominal pain, yellowing of skin or eye(s), unusual tiredness, dark urine, or pale stools.
Caution: Drug interactions may be significant, especially pimozide (avoid), alfentanil, bromocriptine, felodipine, sparfloxacin (avoid), grepafloxacin, methylprednisolone, rifampin, warfarin, benzodiazepines, buspirone, carbamazepine, digoxin, cyclosporine, ergots, disopyramide, tacrolimus, HMG-CoA reductase inhibitors, theophylline, zidovudine, cisapride, others.
Use with caution in persons with liver disease.
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Erythromycin ethylsuccinate ESS®, EryPed® Generics available Pregnancy: B; Lactation: +
Tabs: 400 mg
Chewable Tabs: 200 mg
Oral Suspension: 200 mg/5 mL 400 mg/5 mL
Note: Due to differences in absorption, 200 mg erythromycin ethylsuccinate is approximately equivalent to 125 mg or erythromycin base or estolate. |
Neonates: ≤7 days: 20 mg/kg/day in divided doses every 12 hours >7 days, <1,200 g: 20 mg/kg/day in divided doses every 12 hours >7 days, 1,200-2,000 g: 30 mg/kg/day in divided doses every 8 hours >7 days, >2,000 g: 30-40 mg/kg/day in divided doses every 6-12 hours
Infants and Children: 30-50 mg/kg/day in divided doses every 6 to 8 hours (max 3.2 g/day)
30 mg/kg/day with 200 mg/5 mL 5 kg (11 lb) = 1/4 tsp Q8H 7 kg (15 lb) = 1/4 tsp Q6H 10 kg (22 lb) = 1/2 tsp (2.5 mL) Q8H 14 kg (30 lb) = 1/2 tsp (2.5 mL) Q6H 20 kg (44 lb) = 1 tsp (5 mL) Q8H
Adults: 400-800 mg PO every 6 to 12 hours.
Food: Take 1 hour before or 2 hours after meals. If GI upset occurs may take with food.
Important side effects: Diarrhea, nausea, vomiting, headache, abdominal pain, dizziness, elevated LFTs, superinfection, rash, hearing loss, cardiac arrhythmias. Advise patient to contact provider if prodromal signs of liver dysfunction occur, i.e., abdominal pain, yellowing of skin or eye(s), unusual tiredness, dark urine, or pale stools.
Caution: Drug interactions may be significant, especially pimozide (avoid), alfentanil, bromocriptine, felodipine, sparfloxacin (avoid), grepafloxacin, methylprednisolone, rifampin, warfarin, benzodiazepines, buspirone, carbamazepine, digoxin, cyclosporine, ergots, disopyramide, tacrolimus, HMG-CoA reductase inhibitors, theophylline, zidovudine, cisapride, others.
Use with caution in persons with liver disease.
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Erythromycin and Sulfisoxazole |
Children ≥2 months: Dosing based on erythromycin component: 40-50 mg/kg/day (erythromycin) in divided doses every 6 to 8 hours (max 2 g erythromycin/day).
Erythromycin 200 mg/sulfisoxazole 200 mg/5 mL 6 kg (13 lb) = 1/2 tsp (2.5 mL) Q8H 8 kg (18 lb) = 1/2 tsp (2.5 mL) Q6H 16 kg (35 lb) = 1 tsp (5 mL) Q6H 24 kg (53 lb) = 11/2 tsp (7.5 mL) Q6H ≥32 kg (70 lb) = 2 tsp (10 mL) Q6H
Adults: Erythromycin 400 mg and sulfisoxazole 1200 mg PO every 6 hours.
Food: May be taken with or without meals. Take with food if GI upset occurs. Maintain good hydration.
Important side effects: Diarrhea, nausea, vomiting, headache, abdominal pain, photosensitivity, dizziness, elevated LFTs, superinfection, rash, hearing loss, cardiac arrhythmias. Advise patient to contact provider if prodromal signs of liver dysfunction occur, i.e., abdominal pain, yellowing of skin or eye(s), unusual tiredness, dark urine, or pale stools.
Caution: Drug interactions may be significant, especially pimozide (avoid), alfentanil, bromocriptine, felodipine, sparfloxacin (avoid), grepafloxacin, methylprednisolone, rifampin, warfarin, benzodiazepines, buspirone, carbamazepine, digoxin, cyclosporine, ergots, disopyramide, tacrolimus, HMG-CoA reductase inhibitors, theophylline, zidovudine, cisapride, others.
Use with caution in persons with liver disease, G-6-PD deficiency.
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Pediazole®, Eryzole® Generics available Pregnancy: C; Lactation: Unknown
Oral Suspension: Erythromycin ethylsuccinate 200 mg and sulfisoxazole 600 mg/5 mL |
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Erythromycin Topical Erygel®, EryDerm®, Staticin® Erymax®, Erythra-Derm® Generics available Pregnancy: B or C; Lactation: Unsafe
Gel, topical 2%: 30 mL Solution, topical 1.5% and 2% Ointment, topical 2%: 25 gm Pledgets: 2%
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Adolescent and Adult gel and topical solution: Apply twice daily after cleansing.
May see response in 3-8 weeks; however, may require 12 weeks for full response. Continue as long as satisfactory response is maintained and side effects do not occur.
Important side effects: May cause irritation, drying, pruritus, erythema. Caution: Avoid contact with eye(s) and mucous membranes. |
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Erythromycin Ophthalmic* Ilotycin® Generics available Pregnancy: B; Lactation: Safe Ophthalmic ointment 0.5%
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Children and Adult: Apply 0.5-1 cm ribbon to lower conjunctival sac and gently massage eyelid. After 1 minute, excess ointment may be gently wiped away with sterile gauze. Repeat one or more times daily depending upon infection. |