SKIN - Impetigo - Mild, Nonbullous (Group A Streptococcus, Staphylococcus aureus)
Mupirocin (Bactroban^®) Pregnancy: B; Lactation: Unk Ointment 2%: 15-g and 30-g tubes		Children and Adult: Apply to lesions three times daily for 5-10 days.		Important side effects: Burning, stinging, itching. Avoid contact with eye(s).
Cephalexin (Keflex^®) Generics available Pregnancy: B; Lactation: Unk Tabs: 250 mg, 500 mg, 1 g Caps: 250 mg, 500 mg Oral Susp: 125 mg/5 mL, 250 mg/5 mL		Children: 25-50 mg/kg/day (max 4 g/day) in divided doses two to four times daily for 10-14 days. 125 mg/5 mL @ 25 mg/kg/day (double for 50 mg/kg) 10 kg (22 lb) = ½ tsp (2.5 mL) Q6H 15 kg (33 lb) = ¾ tsp Q6H 250 mg/5 mL @ 25 mg/kg/day (double for 50 mg/kg) 20 kg (44 lb) = ½ tsp (2.5 mL) Q6H 40 kg (88 lb) = 1 tsp (5 mL) Q6H >40 kg = Use adult dose. Adult: 500 mg PO four times daily for 10-14 days.		Food: May take with food if GI upset occurs. Important side effects: GI upset, diarrhea. Reduce dose in renal disease (CrCl <40 mL/min).
Dicloxacillin (Dynapen^®) Generics available Pregnancy: B; Lactation: Unk Caps: 125 mg, 250 mg, 500 mg Oral Susp: 62.5 mg/5 mL, 200 mL		Children ≤40 kg: 25-50 mg/kg/day (max 2 g/day) in divided doses every 6 hours for 10 days. 62.5 mg/5 mL @ 25 mg/kg/day (double for 50 mg) 10 kg (22 lb) = 1 tsp (5 mL) Q6H 15 kg (33 lb) = 1½ tsp (7.5 mL) Q6H 20 kg (44 lb) = 2 tsp (10 mL) Q6H 40 kg (88 lb) = Use adult dose. Children ≥40 kg and Adult: 250-500 mg PO four times daily for 10 days.		Food: Take 1 hour before or 2 hours after meals. Important side effects: Bad taste, GI upset.
Erythromycin estolate or base* An alternative for patients with beta-lactam intolerance.		Children: 30-50 mg/kg/day (max 2 g/day) in two to four divided doses daily for 10 days. Adult: Erythromycin base or estolate 500 mg PO four times daily for 10 days.		Food: May take with or without meals. Take with food if causes GI upset. Important side effects: GI upset, hepatitis.
SKIN - Impetigo Bullous (Staphylococcus aureus)
Amoxicillin/clavulanate (Augmentin^®) Pregnancy: B; Lactation: Unk Q12H Formulations: Tabs: 500 mg/125 mg, 875 mg/125 mg Chewable Tabs: 200 mg/28.5 mg, 400 mg/57 mg Oral Susp: 200 mg/28.5 mg/5 mL, 400 mg/57 mg/5 mL		Children: 40-45 mg amoxicillin component/kg/day (max 1600 mg/day) in divided doses two or three times daily for 10 days. Q12H using 200 mg/5 mL susp @ 45 mg/kg/day 9 kg (20 lb) = 1 tsp (or tab) (5 mL) Q12H 13 kg (29 lb) = 1½ tsp (or tab) (7.5 mL) Q12H 18 kg (40 lb) = 2 tsp (or tabs) (10 mL) Q12H Q12H using 400 mg/5 mL susp @ 45 mg/kg/day 18 kg (40 lb) = 1 tsp (or tab) (5 mL) Q12H 27 kg (59 lb) = 1½ tsp (or tab) (7.5 mL) Q12H 35 kg (77 lb) = 2 tsp (or tabs) (10 mL) Q12H >40 kg = Use adult dose (max 875 mg Q12H). Adult: 500-875 mg twice daily for 10 days. Note: Q12H dosing may improve compliance compared to Q8H dosing.		Food: Take with food to reduce diarrhea. Important side effects: Diarrhea (common), nausea, rash. Use with caution in hepatic disease. Reduce dose in renal disease (CrCl <30 mL/min).
Azithromycin (Zithromax^®) Pregnancy: B; Lactation: Unk Tabs: 250 mg and Z-Pak Oral Susp: 100 mg/5 mL, 200 mg/5 mL		Children ≥6 months: 10 mg/kg/day (max 500 mg) once daily × 1 day, then 5 mg/kg/day (max 250 mg) once daily × 4 days 100 mg/5 mL 10 kg (22 lb) = 1 tsp (5 mL)/day × 1 day, then ½ tsp (2.5 mL) daily for days 2-5. 200 mg/5 mL 20 kg (44 lb) = 1 tsp (5 mL)/day × 1 day, then ½ tsp (2.5 mL) daily for days 2-5. 30 kg (66 lb) = 1.5 tsp/day × 1 day, then ¾ tsp daily for days 2-5. Adult: Dispense one Z-Pak.		Food: Oral suspension should be taken 1 hour before or 2 hours after food. Tablets may be taken without regard to food. Important side effects: Nausea, diarrhea, elevated LFTs.
Clarithromycin (Biaxin^®, Biaxin XL^®) Pregnancy: C; Lactation: Unk Tabs: 250 mg, 500 mg Extended Release Tab (XL): 500 mg Oral Susp: 125 mg/5 mL, 250 mg/5 mL	Children ≥6 months: 15 mg/kg/day (max 1 g/day) in divided doses twice daily for 10 days. 125 mg/5 mL 9 kg (20 lb) = ½ tsp (2.5 mL) Q12H 17 kg (37 lb) 1 tsp (5 mL) Q12H 250 mg/5 mL 25 kg (55 lb) = ¾ tsp Q12H 33 kg (73 lb) = 1 tsp (5 mL) Q12H Adult: 250 mg PO twice daily for 10 days.		Food: Extended release tablet with food. Others without regard to food. Important side effects: Nausea, drug interactions. Reduce dose in renal disease (CrCl <30 mL/min).
Dicloxacillin (Dynapen^®) Generics available Pregnancy: B; Lactation: Unk Caps: 125 mg, 250 mg, 500 mg Oral Susp: 62.5 mg/5 mL, 200 mL	Children ≥40 kg: 25-50 mg/kg/day (max 2 g/day) in divided doses every 6 hours  for 10 days. 62.5 mg/5 mL @ 25 mg/kg/day (double for 50 mg) 10 kg (22 lb) = 1 tsp (5 mL) Q6H 15 kg (33 lb) = 1½ tsp (7.5 mL) Q6H 20 kg (44 lb) = 2 tsp (10 mL) Q6H 40 kg (88 lb) = Use adult dose. Children ≥40 kg and Adult: 500 mg PO four times daily for 10 days.		Food: Take 1 hour before or 2 hours after meals. Important side effects: Bad taste, GI upset.
Erythromycin estolate or base Alternative for persons with beta-lactam intolerance. (E-mycin^®, Ilosone ^®) Generics available Pregnancy: B; Lactation: Unsafe Estolate: Tabs: 500 mg Caps: 250 mg Oral Susp: 125 mg/5 mL, 250 mg/5 mL Base: Tabs: 250 mg, 333 mg, 500 mg Caps: 250 mg	Children: 30-50 mg/kg/day estolate (max 2 g/day) PO in two to four divided doses daily for 10 days. 125 mg/5 mL @ 30 mg/kg/day 4 kg (10 lb) = ½ tsp (2.5 mL) Q12H 5-8 kg (11-18 lb) = 1 tsp (5 mL) Q12H 9-12 kg (20-26 lb) = 1 tsp (5 mL) Q8H 13-16 kg (29-35 lb) = 1 tsp (5 mL) Q6H or 2 tsp (10 mL) Q12H 250 mg/5 mL @ 30 mg/kg/day 13-16 kg (29-35 lb) = 1 tsp (5 mL) Q12H 17-25 kg (37-55 lb) = 1½ tsp (7.5 mL) Q12H or 1 tsp (5 mL) Q8H 26-33 kg (57-72 lb) = 250 mg Q6H or 500 mg Q12H 30-50 kg (66-110 lb) = 500 mg Q8H Adult: Erythromycin base or estolate 500 mg PO four times daily for 10 days		. Food: May take with or without meals. Take with food if causes GI upset. Important side effects: GI upset, hepatitis.