Drug	Typical Dosing

Nitrofurantoin Macrodantin^®, Furadantin^®, Macrobid^® Generics available Pregnancy: B; Lactation: Safe Caps: 25 mg 50 mg 100 mg Macrobid^®: 100 mg Oral Suspension: 25 mg/5 mL 60 mL

Children ≥1 month: 5-7 mg/kg/day in divided doses every 6 hours (max 400 mg/day). UTI prophylaxis 1-2 mg/kg/day as single dose (max 100 mg). Adult: 50-100 mg PO every 6 hours. 2.5/mg/kg/day 10 kg (22 lb) = ^1/4 tsp Q6H 20 kg (44 lb) = ^1/2 tsp (2.5 mL) Q6H 30 kg (66 lb) = 1 tsp (5 mL) Q6H Food: Take with food or milk. Maintain diet adequate in protein and vitamin B complex. Important side effects: May discolor urine. Nausea, vomiting, dizziness, headache, rash, hemolytic anemia, granulocytopenia, thrombocytopenia, hepatitis, jaundice, interstitial pneumonitis, fibrosis. Caution: Contraindicated in women at term or in labor. Use with caution in G-6-PD deficiency, anemia, diabetes, or electrolyte abnormalities. Monitor for pulmonary or hepatic reactions or peripheral neuropathy. Do not use in renal impairment. Ineffective if CrCl <40 mL/min.