EARS - Otitis Externa, Furuncle (Staphylococcus aureus)
Cephalexin (Keflex®) Generics available Pregnancy: B; Lactation: Unk Tabs: 250 mg, 500 mg, 1 g Caps: 250 mg, 500 mg Oral Susp: 125 mg/5 mL, 250 mg/5 mL	Children: 25-50 mg/kg/day (max 4 g/day) in divided doses three to four times daily for 10 days. 125 mg/5 mL @ 25 mg/kg/day (double for 50 mg/kg) 10 kg (22 lb) = 1/2 tsp (2.5 mL) Q6H 15 kg (33 lb) = 3/4 tsp Q6H 20 kg (44 lb) = 1 tsp (5 mL) Q6H 250 mg/5 mL @ 25 mg/kg/day (double for 50 mg/kg) 20 kg (44 lb) = 1/2 tsp (2.5 mL) Q6H 40 kg (88 lb) = 1 tsp (5 mL) Q6H >40 kg = Use adult dose. Adult: 250-500 mg PO four times daily for 10 days.	Food: May take with food if GI upset occurs. Important side effects: GI upset, diarrhea. Reduce dose in renal disease (CrCl <40 mL/min).
Dicloxacillin (Dynapen®) Generics available Pregnancy: B; Lactation: Unk Caps: 125 mg, 250 mg, 500 mg Oral Susp: 62.5 mg/5 mL 200 mL	Children ≤40 kg: 25-50 mg/kg/day (NTE 2 g/day) in divided doses every 6 hours for 10-14 days. 62.5 mg/5 mL @ 25 mg/kg/day (double for 50 mg) 10 kg (22 lb) = 1 tsp (5 mL) Q6H 15 kg (33 lb) = 1½ tsp (7.5 mL) Q6H 20 kg (44 lb) = 2 tsp (10 mL) Q6H 40 kg (88 lb) = Use adult dose Adult: 250-500 mg PO four times daily for 10-14 days.	Food: Take 1 hour before or 2 hours after meals. Important side effects: Bad taste, GI upset.
Amoxicillin/clavulanate (Augmentin^®) Pregnancy: B; Lactation: Unk Q12H Formulations (7:1): Tabs: 875 mg/125 mg Chewable Tabs: 200 mg/28.5 mg, 400 mg/57 mg Oral Susp: 200 mg/28.5 mg/5 mL, 400 mg/57 mg/5 mL Augmentin ES-600 Powder for Oral Suspension (14:1): 600 mg/42.9 mg/ 5 mL .	Children: 80-90 mg amoxicillin component/kg/day (max 1600 mg/day) in divided doses two times daily. If <2 years × 10 days. If ≥2 years × 5-7 days. 14:1 (ES-600) formulation is advised, especially if antibiotic exposure for otitis media in preceding 3 months and either age ≤2 years or daycare attendance. If low likelihood of resistant S. pneumoniae, may use 7:1 formulation; however, limit clavulanate to no more than 10 mg/kg/day (amoxicillin 70 mg/kg/day). Q12H using 600/5 mL susp @ 90 mg/kg/day 8 kg (18 lb) = 3 mL Q12H 12 kg (26 lb) = 4.5 mL Q12H 16 kg (35 lb) = 6 mL Q12H 20 kg (44 lb) = 7.5 mL Q12H 24 kg (53 lb) = 9.0 mL Q12H 28 kg (62 lb) = 10.5 mL Q12H 32 kg (70 lb) = 12.0 mL Q12H 36 kg (79 lb) = 13.5 mL Q12H >40 kg = Experience not available. If low likelihood of resistant S. pneumoniae, may use 7:1 formulation; however, limit clavulanate to no more than 10 mg/kg/day (amoxicillin 70 mg/kg/day). Q12H using 400 mg/57 mg/5 mL suspension @ 70 mg/kg/day: 11 kg (24 lb) = 1 tsp (5 mL) Q12H 17 kg (37 lb) = 1½ (7.5 mL) tsp Q12H 23 kg (51 lb) = 2 tsp (10 mL) Q12H >23 kg = Use adult dose. Adult: 500-875 mg twice daily for 10 days.	Food: Take with food to reduce diarrhea. Important side effects: Diarrhea (common), nausea, rash. May cause nonallergic maculopapular rash. Use with caution in hepatic disease. Reduce dose if renal impairment (CrCl <30 mL/min).