EARS - Otitis Externa, Malignant (Pseudomonas aeruginosa) Comment: Consider urgent ENT, infectious disease consult. Only early, very mild cases appropriate for outpatient therapy. Assess need for IV antibiotics. Usually occurs in diabetic patients.
Ciprofloxacin (Cipro^®) Pregnancy: C; Lactation: Unsafe	Tabs: 250 mg, 500 mg, 750 mg    Adult: 750 mg PO twice daily for 7-14 days. Food: Take 1 hour before or 2 hours after a meal. May take with food if it causes GI upset. Make take 2 hours before or 6 hours after sucralfate, antacids, aluminum, magnesium, calcium, zinc, iron, vitamins, or mineral supplements.	Important side effects: Photosensitivity, dizziness. Reduce dose in renal disease (CrCl <50 mL/min).
Levofloxacin (Levaquin^®) Pregnancy: C; Lactation: Unsafe	Tabs: 250 mg, 500 mg      Adult: 500 mg PO once daily for 7-14 days. Food: Do not take within 2 hours of antacids, magnesium, calcium, zinc, iron, aluminum, sucralfate, vitamins, or mineral supplements.	Important side effects: Photosensitivity, dizziness. Reduce dose in renal disease (CrCl <50 mL/min).
Imipenem/cilastatin IV (Primaxin^®) Pregnancy: C; Lactation: Unk	Other IV drug with good antipseudomonal coverage. Examples include ciprofloxacin, ceftazidime, or a combination of an aminoglycoside and piperacillin.	Adult: 500 mg IV every 6 hours. 7-14 days (or until switch to alternate oral agent is appropriate). Important side effects: Confusion, seizures.