BRONCHOPULMONARY - Pertussis (Bordetella pertussis)
Erythromycin estolate or base Estolate salt recommended. (Ilosone^®, E-mycin^®, Ery-Tab^®) Generics available Pregnancy: B; Lactation: Unsafe Estolate: Tabs: 500 mg Caps: 250 mg Susp: 125 mg/5 mL and 250 mg/5 mL Oral Drops: 100 mg/mL 250 mg/5 mL Q12H × 10 days -   Base: Tabs: 250 mg, 333 mg, 500 mg Caps: 250 mg	Children: 40-50 mg/kg/day Estolate (max 2 g/day) in two to four divided doses daily for 7-14 days. Erythromycin base dose is every 6 hours for 14 days. Erythromycin Estolate 250 mg/5 mL @ 40 mg/kg/day 4-6 kg (10-15 lb) = ^1/2 tsp (2.5 mL) Q12H 7-11 kg (16-25 lb) = 1 tsp (5 mL) Q12H 12-16 kg (26-35 lb) = 1^1/2 tsp (7.5 mL) Q12H 17-25 kg (37-55 lb) = 2 tsp (10 mL) Q12H 26-37 kg (57-81 lb) = 2 tsp (10 mL) Q8H >38 kg (83 lb) = 1,000 mg Q12H Adult: Erythromycin estolate 500 mg PO four times daily for 7-14 days or Erythromycin base 500 mg PO four times daily for 14 days.	Food: May take with or without meals. Take with food if causes GI upset. Important side effects: GI upset, hepatitis.
Azithromycin (Zithromax^®) Pregnancy: B; Lactation: Unk Tabs: 250 mg and Z-Pak (500 mg 1 day, then 250 mg daily 4) Oral Susp: 100 mg/5 mL, 200 mg/5 mL 20 kg child	Children >2 years: 10-12 mg/kg/day (max 500 mg) PO once daily for 5-7 days. 100 mg/5 mL 10 kg (22 lb) = 1 tsp (5 mL) PO once daily for 5-7 days. 200 mg/5 mL 20 kg (44 lb) = 1 tsp (5 mL) Q24H 30 kg (66 lb) = 1^1/2 tsp (7.5 mL) Q24H ³40 kg (88 lb) = 2 tsp (10 mL) Q24H Adolescent ³16 years and Adult: Dispense one Z-Pak.	Food: Oral suspension should be taken 1 hour before or 2 hours after food. Tablets may be taken without regard to food. Important side effects: Nausea, diarrhea,elevated LFTs.
Clarithromycin (Biaxin) Pregnancy: C; Lactation: Unk Tabs: 250, 500 MG XL: 500mg Oral Susp: 125/5 mL	Children >6 months: 15 mg/kg/day (max 1 g/day) PO in divided doses twice daily for 5-7 days 125mg/tsp 9 kg (20 lbs) = ½ tsp (2.5 mL) Q12H 17 kg (37 lbs) = 1 tsp (5 mL) Q12H 250 mg/tsp 25 kg (55lbs) = ¾ tsp Q12H 33 kg (73 lbs) = 1 tsp (5 mL) Q12 H Adult: 500 mg PO BID for 7 days.	Food: Extended degrees tablets with food. Others without regard to food. Important side effects: Nausea, drug interactions.

Trimethoprim/Sulfamethoxazole Considered second-line therapy. (Bactrim^®, Septra^®) Generics available Pregnancy: C; Lactation: Unsafe Single Strength (SS) Tabs: 80 mg/400 mg Double Strength (DS) Tabs: 160 mg/800 mg Oral Susp: 40 mg/200 mg per 5 mL

Children >2 months: 6-12 mg/kg/day TMP component (max 320 mg/day) in divided doses twice daily for 7-14 days. 40 mg/200 mg/5 mL @ 8 mg/kg/day 10 kg (22 lb) = 1 tsp (5 mL) Q12H 20 kg (44 lb) = 2 tsp (10 mL) or 1 SS Tab Q12H 30 kg (66 lb) = 3 tsp (15 mL) or 1^1/2 SS Tab Q12H 40 kg (88 lb) = 4 tsp (20 mL) or 2 SS Tabs or 1 DS Tab Q12H. Adult: 1 DS tablet PO twice daily for 14 days.

Food: May take without regard to food. Encourage fluids. Important side effects: Photosensitivity, rash.