GENITOURINARY - STI, Gonorrhea, Uncomplicated Urethritis, Cervicitis, or Proctitis (Neisseria gonorrhoeae) General statement: After neonatal period, sexual abuse is most common cause of gonococcal infection in preadolescent children. Coinfection with C. trachomatis may be common; consider treating for dual infection.
Ceftriaxone (IM) (Rocephin^®) Pregnancy: B; Lactation: Unk Vials: 250 mg, 500 mg, 1,000 mg	Children and Adult: 125 mg IM 1 ´ dose. Children ³45 kg and Adults: Treat with concomitant azithromycin or doxycycline for presumptive C. trachomatis.		Important side effects: Pain at injection site.
Cefixime (Suprax^®) Pregnancy: B; Lactation: Unk Tabs: 200 mg, 400 mg   Oral Susp: 100 mg/5 mL	Children: 8 mg/kg (max 400 mg) 1´ dose. Coinfection with C. trachomatis may be common; consider treating for dual infection. >50 kg and Adult: 400 mg 1 dose. Children ³45 kg and Adults treat with concomitant azithromycin or doxycycline for presumptive C. trachomatis.		Food: May administer on empty stomach. May administer with food to reduce GI distress. Important side effects: Nausea, diarrhea.
Ciprofloxacin (Cipro^®) Pregnancy: C; Lactation: Unsafe Tabs: 250 mg, 500 mg	³18 years: 500 mg 1 dose. Treat with concomitant azithromycin or doxycycline for presumptive C. trachomatis.		Food: Take on empty stomach 1 hour before or 2 hours after a meal. May take with food if it causes GI upset, but avoid large amounts of dairy products. May take 2 hours before or 6 hours after sucralfate, antacids, aluminum, magnesium, calcium, zinc, iron, sucralfate, vitamins, or mineral supplements. Important side effects: Photosensitivity, dizziness.
Ofloxacin (Floxin^®) Pregnancy: C; Lactation: Unk Tabs: 200 mg, 300 mg, 400 mg	Adult: 400 mg ´1 dose. Treat with concomitant azithromycin or doxycycline for presumptive C. trachomatis.		Food: Take on empty stomach. Do not take within 2 hours of antacids, magnesium, calcium, zinc, iron, aluminum, sucralfate, vitamins, or mineral supplements.
			Important side effects: Nausea, photosensitivity, dizziness.
Azithromycin (Zithromax^®) Pregnancy: B; Lactation: Unk Tabs: 250 mg Powder for Oral Suspension: 1 g	Children ³45 kg and Adult: 1 g ´ 1 dose. Use in conjunction with cefixime, ceftriaxone, ciprofloxacin, or ofloxacin.		Food: 1-g powder packet for oral suspension and tablets may be taken without regard to food. Important side effects: Nausea, diarrhea, elevated LFTs.
Doxycycline (Vibramycin^®) Generics available Pregnancy: D; Lactation: Unsafe Caps: 50 mg, 100 mg   Tabs: 100 mg	Children ³8 years and Adult: 100 mg PO twice daily for 7 days. Use in conjunction with cefixime, ceftriaxone, ciprofloxacin, or ofloxacin.		Food: May take with food if GI upset occurs. Take 1 hour before or 2 hours after antacids, iron, milk, or other dairy products. Take with full glass of water to prevent esophagitis. Important side effects: Photosensitivity, use sunscreen. Esophagitis. May discolor fingernails.
GENITOURINARY - STI, Gonorrhea, Pregnancy, Uncomplicated Urethritis, Cervicitis, or Proctitis (Neisseria gonorrhoeae)
Ceftriaxone (IM) (Rocephin^®) Pregnancy: B; Lactation: Unk Vials: 250 mg, 500 mg, 1,000 mg Vials with 2.1 mL lidocaine for IM injection: 500 mg, 1,000 mg		Adolescent and Adults: 125 mg IM ´ 1 dose. Treat with concomitant erythromycin or amoxicillin for presumptive C. trachomatis.	Important side effects: Pain at injection site.
Spectinomycin (IM) Alternative for cephalosporin allergy. (Trobicin^®) Pregnancy: B; Lactation: Unk IM Injection: 2 g		Adolescents and Adult: 2 g IM × 1 dose. Treat with concomitant erythromycin for presumptive C. trachomatis.
Amoxicillin (Amoxil^®) Generics available Pregnancy: B; Lactation: Safe Caps: 250 mg, 500 mg   Tabs: 500 mg, 875 mg		Adolescents and Adult: 500 mg three times daily for 7 days. Use in conjunction with ceftriaxone, cefixime, or spectinomycin.	Food: May be taken without regard to food. Important side effects: Diarrhea and nausea. May cause nonallergic maculopapular rash.
Cefixime (Suprax^®) Pregnancy: B; Lactation: Unk Tabs: 200 mg, 400 mg		Adolescent and Adult: 400 mg ´ 1 dose. Treat with concomitant erythromycin or amoxicillin for presumptive C. trachomatis.	Food: May administer on empty stomach. May administer with food to reduce GI distress. Important side effects: Nausea, diarrhea.
Erythromycin Base (E-Mycin^®) Generics available Pregnancy: B; Lactation: Unsafe Tabs: 250 mg, 500 mg   Caps: 250 mg		Adolescents and Adult: 500 mg four times daily × 7 days (recommended) or if gastrointestinal intolerance 250 mg four times daily × 14 days. Use in conjunction with ceftriaxone, cefixime, or spectinomycin.	Food: May take with or without meals. Take with food if causes GI upset. Important side effects: GI upset, hepatitis, drug interactions.