GENITOURINARY - STI, Genital Herpes, First Episode (Herpes simplex virus) Not a cure but may reduce duration of outbreak.
Acyclovir (Zovirax^®) Pregnancy: C; Lactation: Safe Caps: 200 mg    Tabs: 400 mg, 800 mg   Oral Susp: 200 mg/5 mL	Children: 80 mg/kg/day (up to equivalent adult doses) in divided doses 3-5 times daily for 7-10 days. 200 mg/ 5 mL @ 80 mg/kg/day 10 kg (22 lb) = 6.7 mL Q8H 15 kg (33 lb) = 10 mL Q8H ³15 kg = Use adult dose. Adults: 400 mg three times daily for 7-10 days or 200 mg five times daily for 7-10 days.		Food: May be taken without regard to food. Encourage fluids. Important side effects: Headache, dizziness, nausea, seizures, bone- marrow suppression, nephrotoxicity. Reduce dose in renal disease (CrCl <10 mL/min).
Famciclovir (Famvir^®) Pregnancy: B; Lactation: Unsafe Tabs: 125 mg, 250 mg, 500 mg	Adult: 250 mg PO three times daily for 7-10 days.		Food: May take without regard to food. Important side effects: Nausea, headache, dizziness. Reduce dose in renal disease (CrCl <40 mL/min).
Valacyclovir (Valtrex^®) Pregnancy: B; Lactation: Unk	Adult: 1,000 mg PO twice daily for 7-10 days.		Food: May take without regard to food. Important side effects: Nausea, headache, dizziness
Tabs: 500 mg, 1,000 mg -			Reduce dose in renal disease (CrCl <30 mL/min).
GENITOURINARY - STI, Genital Herpes, Recurrent (Herpes simplex virus)
Acyclovir (Zovirax^®) Pregnancy: C; Lactation: Safe Caps: 200 mg   Tabs: 400 mg, 800 mg    Oral Susp: 200 mg/5 mL	Children: 80 mg/kg/day (up to equivalent adult doses) in divided doses 2-5 times daily for 5 days. 200 mg/ 5 mL @ 80 mg/kg/day 10 kg (22 lb) = 6.7 mL Q8H 15 kg (33 lb) = 10 mL Q8H ³15 kg = Use adult dose. Adults: 400 mg three times daily for 5 days or 200 mg five times daily for 5 days or 800 mg twice daily for 5 days.		Food: May be taken without regard to food. Encourage fluids. Important side effects: Headache, dizziness, nausea, seizures, bone- marrow suppression, nephrotoxicity. Reduce dose in renal disease (CrCl <10 mL/min).
Famciclovir (Famvir^®) Pregnancy: B; Lactation: Unsafe Tabs: 125 mg, 250 mg, 500 mg	Adult: 125 mg PO twice daily for 5 days.		Food: May take without regard to food. Important side effects: Nausea, headache, dizziness. Reduce dose in renal disease (CrCl <40 mL/min).
Valacyclovir (Valtrex^®) Pregnancy: B; Lactation: Unk Tabs: 500 mg, 1,000 mg	Adult: 500 mg PO twice daily for 5 days.		Food: May take without regard to food. Important side effects: Nausea, headache, dizziness. Reduce dose in renal disease (CrCl <30 mL/min).
GENITOURINARY - STI, Genital Herpes, Suppressive Tx (Herpes simplex virus)
Acyclovir (Zovirax^®) Pregnancy: C; Lactation: Safe Caps: 200 mg Tabs: 400 mg, 800 mg Oral Susp: 200 mg/5 mL	Children: 80 mg/kg/day (max 800-1,000 mg) in divided doses 2-5 times daily. 200 mg/ 5 mL @ 80 mg/kg/day 5 kg (22 lb) = 5 mL Q12H ³10 kg = 10 mL Q12H Adults: 400 mg PO twice daily.		Food: May be taken without regard to food. Encourage fluids. Important side effects: Headache, dizziness, nausea, seizures, bone- marrow suppression, nephrotoxicity. Reduce dose in renal disease (CrCl <10 mL/min).
Famciclovir (Famvir^®) Pregnancy: B; Lactation: Unsafe Tabs: 125 mg, 250 mg, 500 mg	Adult: 250 mg PO twice daily.		Food: May take without regard to food. Important side effects: Nausea, headache, dizziness. Reduce dose in renal disease (CrCl <40 mL/min).
Valacyclovir (Valtrex^®) Pregnancy: B; Lactation: Unk Tabs: 500 mg, 1,000 mg	Adult: 500-1,000 mg PO once daily.		Food: May take without regard to food. Important side effects: Nausea, headache, dizziness . Reduce dose in renal disease (CrCl <30 mL/min).
GENITOURINARY - STI, Genital Herpes, Pregnancy (Herpes simplex virus) General statement: Use of acyclovir and valacyclovir in pregnancy are under investigation, but preliminary evidence has not found them to be detrimental to the fetus.
Acyclovir (Zovirax^®) Pregnancy: C; Lactation: Safe	Adults: 400 mg three times daily for 7-10 days or 200 mg five times daily for 7-10 days.	Food: May be taken without regard to food. Encourage fluids.
Caps: 200 mg -   Tabs: 400 mg, 800 mg -		Important side effects: Headache, dizziness, nausea, seizures, bone- marrow suppression, nephrotoxicity. Reduce dose in renal disease (CrCl <10 mL/min).
Valacyclovir (Valtrex^®) Pregnancy: B; Lactation: Unk Tabs: 500 mg, 1,000 mg	Adult: 1,000 mg twice daily for 7-10 days.	Food: May take without regard to food. Important side effects: Nausea, headache, dizziness. Reduce dose in renal disease (CrCl <30 mL/min).