FACE - Sinusitis - Acute, Mild to Moderate (Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis) >90% of acute sinusitis is viral in nature
Amoxicillin (Amoxil^®) Pregnancy: B; Lactation: Unk	Children: 45-90 mg/kg/day (max 1500 mg/day) in divided doses three times daily for 10-14 days. 250 mg/5 mL at 90 mg/kg/day 8 kg (18 lb) = 1 tsp (5 mL) Q8H 17 kg (37 lb) = 2 tsp (10 mL) Q8H >17 kg = Use adult dose. Adult: 500 mg PO three times daily for 10-14 days.			Food: May take with or without meals. Important side effects: Diarrhea and nausea. May cause nonallergic maculopapular rash. Reduce dose if renal impairment (CrCl <30 mL/min).
Caps: 250 mg, 500 mg Tabs: 500 mg, 875 mg Chewable Tabs: 125, 250 mg Susp: 125 mg/5 mL, 250 mg/5 mL, 400 mg/5 mL Oral drops: 50 mg/mL
Amoxicillin/clavulanate (Augmentin^®) Pregnancy: B; Lactation: Consider Alt Q12H Formulations: Tabs: 500 mg/125 mg, 875 mg/125 mg, 1000 mg/ 62.5 XR Oral Susp: 125 mg /31.25/ 5 mL 250 mg /62.5/ 5 mL 200 mg/28.5 mg/5 mL 400 mg/57 mg/5 mL 600 mg/42.5 mg/ 5 mL Chew: 200, 400 mg Augmentin 600 ES:  Amoxicillin 600mg /42.9 mg	Neonates and infants <3 months: Use 125 mg/31.25 mg/5 mL suspension. 30 mg/kg/day in divided doses every 12 hours Children ≥3 months up to 40 kg: 40-45 mg amoxicillin component/kg/day (max 1600 mg/day) in divided doses two or three times daily for 10-14 days. Q12H using 200 mg/5 mL susp @ 45 mg/kg/day 9 kg (20 lb) = 1 tsp (5 mL) Q12H 13 kg (29 lb) = 1½ tsp (7.5 mL) Q12H 18 kg (40 lb) = 2 tsp (10 mL) Q12H Q12H using 400 mg/5 mL susp @ 45 mg/kg/day 18 kg (40 lb) = 1 tsp (5 mL) Q12H 27 kg (59 lb) = 1½ tsp (7.5 mL) Q12H 35 kg (77 lb) = 2 tsp (10 mL) Q12H >40 kg = Use adult dosing (max 875 mg Q12H ). Adult: 500-875 mg twice daily for 10-14 days. Note: Q12H dosing may improve compliance compared to Q8H dosing.			Food: Take with food to reduce diarrhea. Important side effects: Diarrhea (common), nausea, rash. May cause nonallergic maculopapular rash. Use with caution in hepatic disease. Reduce dose in renal impairment (CrCl <30 mL/min).
Cefpodoxime (Vantin^®) Pregnancy: B; Lactation: Unsafe Tabs: 100, 200 mg Oral Susp: 50 mg/5 mL, 100 mg/5 mL	Children >5 months to 12 years: 10 mg/kg/day (max 400 mg) in divided doses twice daily for 10 days. 100 mg/5 mL @ 10 mg/kg/day 10 kg (22 lb) = 1 tsp (5 mL) Q24H 20 kg (44 lb) = 2 tsp (10 mL) Q24H 30 kg (66 lb) = 3 tsp Q24H 12 years to Adult: 200-400 mg twice daily for 10-14 days			Food: Take tablet with food. Suspension may be taken without regard to food. Important side effects: Diarrhea.
Cefuroxime axetil (Ceftin^®) Pregnancy: B; Lactation: Unsafe Tabs: 125 mg, 250 mg, 500 mg Oral Suspension: 125 mg/5 mL, 250 mg/5 mL	Children >3 months to 12 years: 30 mg/kg/day (max 1,000 mg/day) in divided doses twice daily for 10 days. 125 mg/5 mL @ 30 mg/kg/day 8 kg (18 lb) = 1 tsp (5 mL) Q12H 12.5 kg (27 lb) = 1½ tsp (7.5 mL) Q12H 17 kg (37 lb) = 2 tsp (10 mL) Q12H 25 kg (55 lb) = 3 tsp (15 mL) Q12H 33 kg (73 lb) = Use adult dose. 12 years to Adults: 250-500 mg PO twice daily for 7-14 days.			Food: Take suspension with food. Tablets may be taken without regard to food. Important side effects: Nausea, vomiting, diarrhea.
Doxycycline Vibramycin^® Generics available Pregnancy: D; Lactation: Unsafe Caps: 50 mg 100 mg Tabs: 100 mg Powder for Oral Suspension: 25 mg/5 mL Syrup: 50 mg/5 mL	Children: 2-4 mg/kg/day (max 200 mg/day) in two divided doses. Children ≥8 years and Adult: 50-100 mg twice daily. Use in children <8 years old is generally not advised because tetracyclines can retard skeletal development and stain dental enamel. Doxycycline may have a role in some children <8 years old in certain tick-borne diseases. The dental risk is less than other tetracyclines and is related to duration of use.			Food: May take with food if GI upset occurs. Take 1 hour before or 2 hours after antacids, iron, milk, or other dairy products. Take with full glass of water to minimize esophagitis. Important side effects: Photosensitivity, use sunscreen. Esophagitis, take with full glass of water. May discolor fingernails. Rash, nausea, diarrhea, superinfection, hepatitis. Outdated tetracyclines are toxic and should not be used.
FACE - Sinusitis - Acute, Mild to Moderate with Beta-lactam Allergy (Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis)
Azithromycin (Zithromax^®) Pregnancy: B; Lactation: Unk Tabs: 250 mg Z-Pak Tri-Pak Oral Suspension: 100 mg/5 mL, 200 mg/5 mL		Children ≥6 months: 10 mg/kg/day (max 500 mg) daily × 1 day, then 5 mg/kg/day (max 250 mg) daily × 4 days. 100 mg/5 mL 10 kg (22 lb) = 1 tsp (5 mL)/day × 1 day, then ½ tsp (2.5 mL) daily for days 2-5. 200 mg/5 mL 20 kg (44 lb) = 1 tsp (5 mL)/day × 1 day, then ½ tsp (2.5 mL) daily for days 2-5. 30 kg (66 lb) = 1.5 tsp/day × 1 day, then ¾ tsp daily for days 2-5. Adult: Dispense one Z-Pak.	Food: Suspension, 1 hour before or 2 hours after food. Tablets, without regard to food. Important side effects: Nausea, diarrhea, elevated LFTs.
Clarithromycin (Biaxin^®, Biaxin XL^®) Pregnancy: C; Lactation: Unk Tabs: 250 mg, 500 mg Extended Release Tab (XL): 500 mg Oral Susp:125 mg/5 mL, 250 mg/5 mL		Children ≥6 months: 15 mg/kg/day (max 1,000 mg/day) in divided doses twice daily for 10-14 days. 125 mg/5 mL @ 15 mg/kg/day 9 kg (20 lb) = ½ tsp (2.5 mL) Q12H 17 kg (37 lb) = 1 tsp (5 mL) Q12H 250 mg/5 mL @ 15 mg/kg/day 17 kg (37 lb) = ½ tsp (2.5 mL) Q12H 25 kg (55 lb) = ¾ tsp Q12H 33 kg (73 lb) = 1 tsp (5 mL) Q12H Adult: 500 mg PO twice daily or 1 g XL PO once daily for 10-14 days.	Food: Extended release tablet with food. Others without regard to food. Important side effects: Nausea.
Erythromycin estolate or base (Ilosone^®, E-mycin^®, Ery-Tab^®) Generics available Pregnancy: B; Lactation: Unsafe Estolate: Tabs: 500 mg Caps: 250 mg Oral Susp: 125 mg/5 mL 250 mg/5 mL Base: Tabs: 250 mg, 333 mg, 500 mg Caps: 250 mg, 500 mg PO		Children: 20-40 mg/kg/day estolate (max 2 g/day) in two to four divided doses daily for 10-14 days. 125 mg/5 mL @ 20 mg/kg/day 4-6 kg (10-15 lb) = ½ tsp (2.5 mL) Q12H 7-11 kg (16-25 lb) = 1 tsp (5 mL) Q12H 12-16 kg (26-35 lb) = 1½ tsp (7.5 mL) Q12H 250 mg/5 mL @ 20 mg/kg/day 17-25 kg (37-55 lb) = 1 tsp (5 mL) Q12H 26-37 kg (57-81 lb) = 1½ tsp (7.5 mL) Q12H >38 kg (83 lb) = 500 mg Q12H Adult: Erythromycin base or estolate 500 mg PO four times daily for 10-14 days.	Food: May take with or without meals. Take with food if causes GI upset. Important side effects: GI upset, hepatitis.
Trimethoprim/Sulfamethoxazole (Bactrim^®, Septra^®) Generics available Pregnancy: C; Lactation: Unsafe Single Strength (SS) Tabs: 80 mg/400 mg Double Strength (DS) Tabs: 160 mg/800 mg Oral Susp: 40 mg/200 mg per 5 mL		Children >2 months: 8-10 mg/kg/day TMP component (max 320 mg/day) in divided doses twice daily for 10-14 days. 8-10 mg/kg/day @ 40 mg/200 mg/5 mL 10 kg (22 lb) = 1 tsp (5 mL) Q12H 20 kg (44 lb) = 2 tsp (10 mL) or 1 SS Tab Q12H 30 kg (66 lb) = 3 tsp (15 mL) or 1½ SS Tab Q12H 40 kg (88 lb) = 4 tsp (20 mL) or 2 SS Tabs or 1 DS Tab Q12H Adult: 1 DS Tab PO twice daily for 10-14 days.	Food: May take without regard to food. Encourage fluids. Important side effects: Photosensitivity, rash. Reduce dose if renal impairment (CrCl <30 mL/min).
FACE - Sinusitis - Acute - Failed Therapy or Antibiotic Use in the Past 4-6 Weeks (Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis)
Levofloxacin (Levaquin^®) Pregnancy: C; Lactation: Unsafe Tabs: 250 mg, 500 mg		Adult: 500 mg PO once daily for 10-14 days.	Food: May take with or without meals. Do not take within 2 hours of antacids, magnesium, calcium supplements, zinc, aluminum, sucralfate, vitamins, or minerals (iron or zinc). Important side effects: Photosensitivity, dizziness. Reduce dose if renal impairment (CrCl <50 mL/min).