Drug

 

 

Typical Dosing

 

 

Tetracycline

Sumycin®, Tetracap®

Generics available

Pregnancy: D; Lactation: Unsafe

 

Caps:

100 mg 250 mg 500 mg

 

Tabs:

50 mg, 500 mg

 

Oral Suspension:

125 mg/5 mL

 

Children ≥8 years: 25-50 mg/kg/day in divided doses four times daily (max 3 g/day).

 

Adolescent and Adult: 250-500 mg PO two to four times daily.

Food: Take 1 hour before or 2 hours after meals. Take with full glass of water to minimize esophagitis. Do not take within 3 hours of antacids, iron, milk, or other dairy or calcium products.

 

Important side effects: Photosensitivity (use sunscreen), esophagitis. May discolor fingernails. Rash, nausea, vomiting, diarrhea, superinfection, hepatitis, damage to developing bones and teeth, renal damage.

 

Outdated tetracyclines are toxic and should not be used.

Reduce dose in liver disease or renal disease:

CrCl 50-80 mL/min administer usual dose every 8-12 hours.

CrCl 10-50 mL/min administer usual dose every 12-24 hours.

CrCl <10 mL/min administer usual dose every 24 hours.