Drug

 

 

Typical Dosing

 

 

Valacyclovir

Valtrex®

Pregnancy: B; Lactation: Unk

Tabs: 500 mg 1,000 mg

 

Children: Safety and efficacy in children have not been established.

Adult: 500 mg PO 2 times daily to 1 g three times daily.

Food: May be taken without regard to food. Maintain good hydration.

Important side effects: Nausea, headache, diarrhea, dizziness, renal

Dysfunction, HUS/TTP.

 

Reduce dose in renal disease:

If usual dose is 1 g every 8 hours and:

CrCl 30-49 mL/min, then use 1 g every 12 hours

CrCl 10-29 mL/min, then use 1 g every 24 hours

CrCl <10 mL/min, then use 500 mg every 24 hours

 

If usual dose is 500 mg every 12 hours and:

CrCl <30 mL/min, then use 500 mg every 24 hours