Drug	Typical Dosing

Acyclovir Zovirax^® Generics available Pregnancy: Use with caution Lactation: Consider Alt Caps: 200 mg Tabs: 400 mg, 800 mg Suspension: 200 mg/5 mL

For HSV Children ≥2 years: <40 kg: 20 mg/kg (maximum of 800 mg/dose) PO 4 times daily for 5 days. ≥40 kg: 800 mg PO 4 times daily for 5 days. Adults: Acute Varicella 800 mg PO five times daily (treatment of acute herpes zoster). CrCl <25 mL/min use 200 mg Q8h CrCl <10 mL/min use 200mg Q12h Oral HSV 400mg Q8h or 200 mg 5x daily ( Consider Valacyclovir ) CrCl <25 mL/min use 200mg Q8h CrCl <10 mL/min use 200mg Q12h Food: May take without regard to food. Maintain good hydration. Important side effects: Headache, nausea, rash. Crystallization in renal tubes and renal dysfunction—maintain good hydration. CNS changes include lethargy, confusion, hallucinations, seizures, agitation, and coma.